Pterostilbene: The Ultimate Resveratrol Killer?

The “Mediterranean diet” is what you need to do if you want to love a longer healthier life!

No, it’s not just the Mediterranean diet, it is regularly consuming red wine that extends your life!


No wait, it’s not the red wine, it’s the compound resveratrol found within red wine that is the fountain of youth!

Fools! It is not the diet, the wine, or the resveratrol, it is pterostilbene, a super-absorbable dimethylated derivative of resveratrol that is really the holy grail of supplements.

No, it is not a dinosaur, and yes, resveratrol is one of the most promising over-the-counter supplements currently receiving a ton of hype within the biohacking world.

TL;DR: There is growing evidence that pterostilbene is indeed better than resveratrol supplementation alone. The prices are coming down and it can regularly be had for cheap via online retailers like Amazon.

What Is Pterostilbene?

Simply put, it is a much more absorbable antioxidant than resveratrol found naturally in most dense quantities in blueberries, a long-known antioxidant superfood.

It has promising clinical evidence to support:

  • Can reduce blood pressure
  • Can assist in weight loss
  • Can increase cognitive function
  • Can protect against malignant cell damage
  • Helps repair testicles (in rats)
  • May delay retina damage in the eye amongst diabetic patients (in vitro)
  • Protective properties within the liver (in rats)
  • Anabolic properties (increase ATP and thus muscle mass)
  • Potential cancer battling properties (including breast cancer, colon cancer, lung cancer, prostate cancer, pancreatic cancer, and ovarian cancer)

Seems a little too good to be true no?

Well, man of the benefits were seen with rats and have not yet been tested on humans, however rats are very close genetically speaking so when there is clear success with rat studies there is reason to be excited as there may be crossover with humans.

Pterostilbene vs. Resveratrol: Know The Difference!

One of the biggest reasons pterostilbene is so awesome because unlike so many other “miracle supplements”, it can cross the blood-brain barrier.

Unlike resveratrol, pterostilbene has two methoxy groups instead of hydroxy groups found in resveratrol.

difference between resveratrol and pterostilbene

This means pterostilbene is 80% bioavailable, meaning 80% of ingested supplement can be utilized by the body, as opposed to only 20% for resveratrol.

It also stays in the blood system much longer than resveratrol (half life of 105 minutes vs resveratrol’s 14 minutes).

So, while resveratrol gets most of the media spotlight recently, we think largely because of it’s occurance in wine (and people looooove wine), it is actually the humble cousin pterostilbene that looks to be the real all-star here.

On Amazon the supplement prices are pretty comparable, so choosing ptero over resvera seems like a no-brainer.

Bestseller No. 1
Pterostilbene Supplement 100mg Capsules (Third Party Tested) 60 Capsules, Superior to Resveratrol, Antioxidant for Longevity Support (Non-GMO, Gluten Free) by Double Wood
  • Third Party Tested and Manufactured in the USA from Globally Sourced Ingredients; Doublewood Pterostilbene capsules are third party tested and Manufactured in the USA from Globally Sourced Ingredients
SaleBestseller No. 2
Jarrow Formulas Pterostilbene 50mg for Antioxidant Support, Dietary Supplement Supports Healthy Aging, 60 Veggie Capsules, 60 Day Supply
  • Antioxidant Support: One 60 count bottle of Jarrow Formulas Pterostilbene 50 mg for up to antioxidant support(1)
SaleBestseller No. 3
Pterostilbene with 98% Trans-Resveratrol, 200mg Per Serving, 200 Capsules | Naturally Sourced from Wild Blueberries – Antioxidant Supplement for Healthy Aging Support – Non-GMO
499 Reviews
Pterostilbene with 98% Trans-Resveratrol, 200mg Per Serving, 200 Capsules | Naturally Sourced from Wild Blueberries – Antioxidant Supplement for Healthy Aging Support – Non-GMO
  • Extra strength trans-pterostilbene capsules, 200mg per serving enhanced with 98% pure trans-resveratrol, easily absorbed bioavailable trans forms, naturally derived from wild harvested blueberries.

Are There Any Side Effects?

Nothing in life is free. This even pertains to miracle supplements like pterostilbene. If you consume more than 500mg, which is over 8x the recommended amount, side effects include:

  • Stomach cramping
  • Diarrhea
  • Increased LDL cholesterol

In terms of toxicity and safety, rats were given 500x what a human could consume (relative to body size) and no rats died or exhibited toxic side effects.

There have been no major headlines regarding negative side effects and as long as consumed within suggested dosages it should be a very well-tolerated supplement.

Can It Be Used For Bodybuilding?

All of the above listed benefits overlap with bodybuilding, like managing cell mutations, increasing ATP, lowering blood pressure and increasing cognitive function.

Personally, when supplementing with Vitamonk’s pterostilbene product we noticed intensely focused workouts and pretty impressive pumps.

[easyazon_image align=”center” height=”500″ identifier=”B01KXVA6GS” locale=”US” nw=”y” nf=”y” src=”” tag=”skinyoke-20″ width=”500″]

Now, this can’t be 100% attributed to the pterostilbene supplement alone as it was taken pre-workout along with a full meal (scrambled eggs and sausage) as well as a full-spectrum pre-workout (Musclepharm’s Assault Black).

So how much pterostilbene contributed to the intense workouts and pumps and how much of it was interaction with whole food and pre-workout consumption.

Given all the non-bodybuilding-specific benefits this is definitely worth working into a morning nutrition stack on top of a solid multi-vitamin, fish oil and glucosamine.

Where’s the Cheapest Place to Buy?

Amazon is the best place to buy pterostilbene simply because they have the largest selection and there are so many brands that you can find at least one that is on sale during any given month of the year.

Some of the top brands in terms of dosing, purity and reliability include:

Vitamonks Pterostilbene (personally tested, highly recommended)

Jarrow Formulas Natural Source Pterostilbene

Now Pterostilbene & Resveratrol (two-in-one supplement)

Mental Refreshment: Pterostilbene

This supplement is most beneficial when taken over an extended period of time so it’s worth grabbing two or three bottles.

The key differences with most brand seems to be whether the pterostilbene is naturally sourced or synthesized.

Last update on 2024-06-23 / Affiliate links / Images from Amazon Product Advertising API

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